Jacques Prost

Curie Institute, Paris Curie Institute, Paris

Examples of epithelial dynamics

Fluids and Materials Seminar

11th July 2023, 1:00 pm – 2:00 pm
Fry Building, Fry 2.04

I will present a few examples of non-trivial epithelium dynamical behavior. In particular, I will describe how a nematic epithelium can be totally at rest on a narrow flat stripe and spontaneously adopt a shearing motion on broader flat stripes. Such shearing motions are observed in cancer invasion. In physiological conditions substrates are rarely flat. I will then describe situations in which the stripes have the shape of "hills and valleys" and discuss the complex state diagrams which result from the existence of spatially varying substrate curvature. I will then describe experiments probing the behaviour of epitheliums in hollow cylinders and on fibers, situations physiologically relevant. A spectacular spontaneous azimuthal rotation is observed and a generalized hydrodynamic theory allows to understand this polar symmetry breaking. Last, I will describe another situation mimicking the role of ordered extra-cellular fibers. Again, a symmetry breaking to a spontaneously moving state is observed which can be understood both with a continuum theory including fluctuations and appropriate simulations.

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