Emanuele Paci

University of Leeds

Models for molecular biophysical data

Fluids and Materials Seminar

12th December 2019, 2:00 pm – 3:00 pm
Fry Building, LG.22

Molecules, and specifically polymers, are the building blocks of every living organism. In our laboratory we use computation to analyse properties of models of such molecules, and proteins in particular. We also use computation to generate phenomenological models of experimental data, and assess such models against microscopic ones. I will broadly introduce my research and present results on two different topics.
One concerns the interpretation of of single molecule force spectrometry and end-to-end contact formation measurements and the relation between generic polymer properties and protein-specific ones.
Another topic is the extraction of high-resolution structural information from a high-throughput technique called hydrogen-deuterium exchange probed my mass spectrometry: this is an example of how suitable models increases the amount of information that can in principle be obtained from increasingly available experimental data.

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